Ancient Nutrition SBO Probiotics Ultimate

MSRP: $59.95 - $299.70


Tired of probiotics that don’t make a real difference? This SBO Probiotics formula brings you Ancient Nutrition’s highest CFU count, plus digestion-specific superfoods, prebiotics and postbiotics for powerful gut benefits.


Key Ingredients

Vitamins and minerals from real food sources, paired with time-tested superfood ingredients.


Superfood Support

Designed for ultimate gut support, this SBO probiotic formula brings you diverse superfoods like organic fermented ginger root, turmeric root and black pepper fruit (all used for centuries to support optimal gut health). Fermentation works to unlock important nutrients and compounds within the ingredient, which helps make it easier for your body to absorb — so you’re getting more out of the supplements you’re taking.

bacteria on blue plate

Clinically Studied Probiotics

Every serving contains 50 billion CFUs** of proprietary, clinically studied Saccharomyces boulardii, Bacillus clausii, Bacillus coagulans and Bacillus subtilis. With the exception of Saccharomyces boulardii (which is a yeast that acts as a probiotic), these four strains are soil-based organisms or SBO probiotics: microbes that naturally occur in the soil. SBOs are uniquely resilient and don’t require refrigeration. They’re designed to thrive in your gut by creating an environment that promotes healthy bacteria – unlike other common probiotics strains, which often can’t even survive at room temperature.

bacteria on white plate

Prebiotics & Postbiotics

We take a trifecta approach to gut health by pairing clinically studied probiotics with prebiotics and postbiotics. Prebiotics act as fuel for probiotics, and postbiotics are the metabolites (enzymes and organic acids) that are created by probiotics. Together, they provide powerful support for digestive health.


  • 50 billion shelf-stable CFUs per serving** (no refrigeration needed)
  • Supports healthy digestive and immune system function*
  • Supports healthy bowel transit time*
  • Reduces occasional constipation, gas and bloating*
  • Promotes healthy elimination*
  • Featuring soil-based organisms (SBOs) probiotics, prebiotics & postbiotics

Suggested Usage

Adults take 2 capsules daily with 8 ounces of water

We recommend taking the capsules on an empty stomach, either when you first wake up or right before bed

Not intended for children

Product Facts

Form: Capsule

Serving Size: 2 Capsules

Number of Servings: 30

Product Weight: 3.5 ounces

Dietary Restrictions

  • Gluten Free
  • Made Without Grains
  • Made Without Dairy
  • Made Without Soy
  • Made Without Nuts
  • Vegan
  • Vegetarian/Plant Based
  • Keto Friendly
  • Paleo Friendly
  • BPA Free
ingredient research

Clinically Studied Ingredients

Whenever possible, Ancient Nutrition believes in using ingredients backed by clinical studies. “Clinically studied” means their ingredient is a) supported by proven research, b) backed by peer-reviewed studies and c) tested for efficacy, safety and transparency. Using clinically studied ingredients means that when Ancient Nutrition makes claims about their products, they really mean them.

Frequently Asked Questions

Ancient Nutrition's Dr. Josh Axe
Dr. Axe Answers

Ancient Nutrition co-founder, chiropractor, clinical nutritionist and certified doctor of natural medicine is here to answer your questions!

What do each of the probiotic strains do?

Bacillus coagulans is an incredibly resilient SBO probiotic strain that is actually activated in the harsh, acidic environment of the stomach. It helps support gut function and reduces occasional gas, bloating and constipation, as well as helps maintain healthy gut microflora, healthy bowel transit time* and more.

Bacillus subtilis is naturally found in the environment and plants. It’s a tough strain that helps support a healthy immune system and inflammation response.*

Bacillus clausii is like the other strains, has the unique ability to withstand harsh environments that other probiotics can’t. It’s been used in Europe for over fifty years and helps to support digestive health.

Saccharomyces boulardii is actually a yeast, but it acts as a probiotic. It helps support a healthy immune system, regular bowel function* and more. It’s also one of the few yeasts that survives best at human body temperature, giving it the capacity to thrive in the gut.

Do I need to refrigerate these probiotics?

Our SBOs arrive dormant and are stable at room temperature, without refrigeration.

Why should I give my gut support?

Fact: Most Americans don’t consume enough probiotics in their diet due to modern processed foods, soil depletion and more. I believe most people are in need of probiotic support.

Here’s why: Thanks to prescription antibiotics, high carbohydrate diets, fluoridated tap water and high levels of stress, the good bacteria in our guts are often diminished, and our bodies can’t replace them at the rate required for optimal health.

Many probiotics health benefits are gut- and digestion-related, so here are a few key reasons why gut health, in general, is so important to overall health:

Up to 80% of the immune system is housed in the gut.

Between 80% to 90% percent of the body’s serotonin, often referred to as a feel good or happy chemical which acts as a neurotransmitter, is found in the gut. Serotonin is thought to have many effects on the body, including the areas of digestion, sleep, memory, behavior and more.

Every bodily cell, tissue and organ depend on proper nutrient absorption and assimilation of food through healthy digestion, and, generally speaking, probiotics can play a supporting role in that.

When will I start to notice a difference?

Everyone is different, and will have a different experience when using the products. We suggest giving any new product a chance for 90 days. However, some people will experience digestive support as soon as they start.

What is the right amount of CFUs to be getting every day?

It varies. For most people, I recommend a CFU count anywhere between 25 to 100 billion. Our SBO Ultimate features 50 billion CFU** per serving. Our other SBO Probiotics capsules feature 25 billion CFU** per serving, and the SBO Gummy features 10 billion CFU** per serving.

What’s the best time to take probiotics?

To help support absorption and colonization in the gut, we recommend taking probiotic capsules (or gummies) on an empty stomach, either when you first wake up or right before bed (roughly 2–3 hours after your last meal).

How is this product different from the probiotics in your Ancient Probiotics line?

The main difference is that this SBO Probiotics line features primarily soil-based, spore-forming organisms, and Ancient Probiotics features mostly non-spore forming cultures (Lactobacilli and Bifidobacteria strains) but with a soil-based probiotic (Bacillus coagulans) and a high-powered yeast that acts as a probiotic (Saccharomyces boulardii).

The strains in SBO Probiotics typically populate differently in your gut than the live cultures in Ancient Probiotics, so they are great to take together for more strain diversity.

Ancient Probiotics varieties feature anywhere between 25 billion and 100 billion CFU** per serving, and SBO Probiotics features 25 billion CFU** to 50 billion CFU** per serving.

Soil-based organisms are generally more survivable than live cultures, which is why there are 16-17 strains of probiotics in Ancient Probiotics and three strains in SBO Probiotics and one beneficial yeast.


*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult your physician before using any supplement.

**At time of manufacture

Additional information

Pack Size

1, 3, 6


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